Bone Graft Substitute:
More than a million bone graft procedures are performed worldwide each year, with approximately 500,000 of those occurring in the United States. The current gold standard for these procedures is the use of autograft material – bone from the patient. In the case of autografts, material is limited, and complications with donor site morbidity and extra surgery can arise. Synthetic grafts based on collagen and hydroxyapatite have found widespread success as an alternative to autografts.
OrteoPoniX is developing a collagen/hydroxyapatite bone graft substitute scaffold, based on research done in the Wei laboratory, which mimics the chemical composition of natural bone. Unlike other available bone graft substitutes, OrteoPoniX’s scaffold contains a morphology similar to that of lamellar bone, improving scaffold mechanical properties and resulting in decreased bone forming time in small animal models. Work is currently being conducted to scale-up scaffold fabrication, evaluate its performance in larger animal models, and evaluate its use as a drug delivery platform.